小児・成人の侵襲性肺炎球菌感染症の疫学情報

研究班の業績

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小児疫学

  1. Oishi T, Ishiwada N, Matsubara K, Nishi J, Chang B, Tamura K, Akeda Y, Ihara T, Nahm MH, Oishi K, the Japanese IPD Study Group.　Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease.　Vaccine. 31: 845-9, 2013
  2. Ishiwada N, Hishiki H, Nagasawa K, Naito S, Sato Y, Chang B, Sasaki Y, Kimura K, Ohnishi M, Shibayama K. The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines. Vaccine. 32:5425-5431, 2014
  3. Chang B, Wada A, Hosoya M, Oishi T, Ishiwada N, Oda M, Sato T, Terauchi Y, Okada K, Nishi J, Akeda H, Kamiya H, Ohnishi M, Ihara T, and the Japanese Invasive Disease Study Group.Characteristics of group B Streptococcus isolated from infants with invasive infections: A population-based study in Japan. Jpn J Infect Dis. 67:356-360, 2014
  4. Tamura K, Matsubara K, Ishiwada N, Nishi J, Ohnishi H, Suga S, Ihara T, Chang B, Akeda Y, Oishi K; Japanese IPD Study Group. Hyporesponsiveness to the infecting serotype after vaccination of children with seven-valent pneumococcal conjugate vaccine following invasive pneumococcal disease.　Vaccine. 32: 1444-50, 2014
  5. Suga S, Chang B, Asada K, Akeda H, Nishi J, Okada K, Wakiguchi H, Maeda A, Oda M, Ishiwada N, Saitoh A, Oishi T, Hosoya M, Togashi T, Oishi K, Ihara T. Nationwide population-based surveillance of invasive pneumococcal disease in Japanese children: Effects of the seven-valent pneumococcal conjugate vaccine. Vaccine. 33, 6054-6060, 2015.
  6. Hoshino T, Hachisu Y, Kikuchi T, Tokutake S, Okui H, Kutsuna S, Fukasawa C, Murayama K, Oohara A, Shimizu H, Ito M, Takahashi Y, Ishiwada N. Analysis of Haemophilus influenzae serotype f isolated from three Japanese children with invasive H. influenzae infection. J Med Microbiol. 64: 355-8, 2015
  7. Suga S, Ishiwada N, Sasaki Y, Akeda H, Nishi J, Okada K, Fujieda M, Oda M, Asada K, Nakano T, Saitoh A, Hosoya M, Togashi T, Matsuoka M, Kimura K, Shibayama K. A nationwide population-based surveillance of invasive Haemophilus influenzae diseases in children after the introduction of the Haemophilus influenzae type b vaccine in Japan.　Vaccine. 36:5678-5684, 2018.
  8. Sano T, Suzuki T, Nishigori A, Miyatake C, Koizumi S, Kaizu K, Fujita A, Kamisago M, Chang B, Ishiwada N, Asano T. The incidence of pediatric invasive bacterial diseases in Nippon Medical School Chiba Hokusoh Hospital before and after the introduction of conjugate vaccines. J Nippon Med Sch 85: 34-8, 2018
  9. Naito S, Takeuchi N, Ohkusu M, Takahashi-Nakaguchi A, Takahashi H, Imuta N, Nishi J, Shibayama K, Matsuoka M, Sasaki Y, Ishiwada N. Clinical and bacteriologic analysis of nontypeable Haemophilus influenzae strains isolated from children with invasive diseases, Japan, 2008-2015. J Clin Microbiol 56. pii: e00141-18, 2018
  10. Ohkusu M, Takeuchi N, Ishiwada N, Ohkusu K. Clonal spread of serotype 12F ST4846 Streptococcus pneumoniae. J Med Microbiol. 2019; 68:1383-90.
  11. Hoshino T, Takeuchi N, Ohkusu M, Hachisu Y, Hirose S, Fukasawa C, Kubota T, Ishida M, Watanabe H, Oishi K, Ishiwada N. Identification of Haemophilus influenzae serotype e strains missing the fucK gene in clinical isolates from Japan. J Med Microbiol. 68: 1534-9, 2019
  12. Kawabata T, Tenokuchi Y, Yamakuchi H, Sameshima H, Katayama H, Ohta T, Tokunaga M, Takezaki T, Tamae S, Nakamura T, Chang B, Kodama Y, Imuta N, Ooka T, Okamoto Y, Suga S, Nishi J. Concurrent Bacteremia Due to Non-vaccine Serotype 24F Pneumococcus in Twins: A Rapid Increase in Serotype 24F-invasive Pneumococcal Disease and its High Invasive Potential.　Pediatr Infect Dis J. 39(1):85-87, 2020

成人疫学

  1. Fukusumi M, Chang B, Tanabe Y, Oshima K, Maruyama T, Watanabe H, Kuronuma K, Kasahara K, Takeda H, Nishi J, Fujita J, Kubota T, Sunagawa T, Matsui T, Oishi K, the Adult IPD Study Group. Invasive pneumococcal disease among adults in Japan, April 2013 to March 2015: Disease characteristics and serotype distribution. BMC Infect Dis 2017 Jan 3;17(1):2. doi: 10.1186/s12879-016-2113-y.
  2. Ikuse T, Habuka R, Wakamatsu Y, Nakajima T, Saitoh N, Yoshida H, Chang B, Morita M, Ohnishi M, Oishi K, Saitoh A. Local outbreak of Streptococcus pneumoniae serotype 12F caused by high morbidity and mortality among children and adults. Epidemiol Infect 146:1793-6,2018
  3. Shimbashi R, Chang B, Tanabe Y, Takeda H, Watanabe H, Kubota T, Kasahara K, Oshima K, Nishi J, Maruyama T, Kuronuma K, Fujita J, Ikuse T, Kinjo Y, Suzuki M, Kerdsin A, ShimadaT, Fukusumi M, Tanaka-Taya K, Matsui T, Sunagawa T, Ohnishi M, Oishi K, and the Adult IPD Study Group.　Epidemiological and clinical features of invasive pneumococcal disease caused by serotype 12F in adults, Japan. PLoS One 2019 Feb 21;14(2):e0212418. doi: 10.1371/journal.pone.0212418. 
  4. Takeda H, Sato C, Chang B, Nishidzuka M, Watanabe M, Yamamoto T, Suzuki H, Oishi K, Tsuchida F. Changes in the pneumococcal vaccine serotypes in adult noninvasive pneumonia after the introduction of pneumococcal conjugate vaccine for children. J Global Infect Dis 11: 30-5, 2019
  5. Hoshino T, Takeuchi N, Ohkushu M, Hirose S, Fukusawa C, Kubota T, Ishida M, Watanabe H, Oishi K, Ishiwada N. Identification of Haemophilus influenzae serotype e strains missing the fucK gene in clinical isolates from Japan. J Med Microbiol. 68(10):1534-9,2019.
  6. Shimbashi R, Suzuki M, Chang B, Watanabe H, Tanabe Y, Kuronuma K, Oshima K, Maruyama T, Takeda H, Kasahara K, Fujita J, Nishi J, Kubota T, Tanaka-Taya K, Matsui T, Sunagawa T, Oishi K, and the Adult IPD Study Group. Effectiveness of 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease in adults, Japan 2013-2017. Emerg Infect Dis. 26(19): 2378-86,2020
  7. Ohshima N, Akeda Y, Nagai H, Oishi K. Immunogenicity and safety after the third vaccination with the 23-valent pneumococcal polysaccharide vaccine in elderly patients with chronic lung disease. Human Vaccine Immunother 2020 Feb 12:1-7. doi: 10.1080/21645515.2020.1718975.
  8. Chang B, Kinjo Y, Morita M, Tamura K, Watanabe H, Tanabe Y, Kuronuma K, Fujita J, Oshima K, Maruyama T, Abe S, Kasahara K, Nishi J, Kubota T, Ohnishi M, Suga S, Oishi K, and the Adult IPD Study Group. Distribution and variation of serotypes and pneumococcal surface protein A clades of Streptococcus pneumoniae strains isolated from adult patients with invasive pneumococcal disease in Japan. Front Cell Infect Microbiol. (in press).
  9. Uehara T, Morino S, Oishi K, Nakamura Y, Togashi N, Imaizumi M, Nishimura S, Okada S, Yara A, Fukushima H, Imagawa K, Takada H. Pneumococcal Serotype-specific Opsonophagocytic Activity in Interleukin-1 Receptor-associated Kinase 4-deficient Patients.Pediatr Infect Dis J (in press)