小児・成人の侵襲性肺炎球菌感染症の疫学情報

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小児疫学

侵襲性肺炎球菌感染症の業績

  1. Oishi T, Ishiwada N, Matsubara K, Nishi J, Chang B, Tamura K, Akeda Y, Ihara T, Nahm MH, Oishi K, the Japanese IPD Study Group. Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease. Vaccine. 31: 845-9, 2013
  2. Ishiwada N, Hishiki H, Nagasawa K, Naito S, Sato Y, Chang B, Sasaki Y, Kimura K, Ohnishi M, Shibayama K. The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines. Vaccine. 32: 5425-5431, 2014
  3. Tamura K, Matsubara K, Ishiwada N, Nishi J, Ohnishi H, Suga S, Ihara T, Chang B, Akeda Y, Oishi K; Japanese IPD Study Group. Hyporesponsiveness to the infecting serotype after vaccination of children with seven-valent pneumococcal conjugate vaccine following invasive pneumococcal disease.　Vaccine. 32: 1444-50, 2014
  4. Suga S, Chang B, Asada K, Akeda H, Nishi J, Okada K, Wakiguchi H, Maeda A, Oda M, Ishiwada N, Saitoh A, Oishi T, Hosoya M, Togashi T, Oishi K, Ihara T. Nationwide population-based surveillance of invasive pneumococcal disease in Japanese children: Effects of the seven-valent pneumococcal conjugate vaccine. Vaccine. 33, 6054-6060, 2015.
  5. Sano T, Suzuki T, Nishigori A, Miyatake C, Koizumi S, Kaizu K, Fujita A, Kamisago M, Chang B, Ishiwada N, Asano T. The incidence of pediatric invasive bacterial diseases in Nippon Medical School Chiba Hokusoh Hospital before and after the introduction of conjugate vaccines. J Nippon Med Sch 85: 34-8, 2018
  6. Ohkusu M, Takeuchi N, Ishiwada N, Ohkusu K. Clonal spread of serotype 12F ST4846 Streptococcus pneumoniae. J Med Microbiol. 2019; 68: 1383-90.
  7. Kawabata T, Tenokuchi Y, Yamakuchi H, Sameshima H, Katayama H, Ohta T, Tokunaga M, Takezaki T, Tamae S, Nakamura T, Chang B, Kodama Y, Imuta N, Ooka T, Okamoto Y, Suga S, Nishi J. Concurrent Bacteremia Due to Non-vaccine Serotype 24F Pneumococcus in Twins: A Rapid Increase in Serotype 24F-invasive Pneumococcal Disease and its High Invasive Potential.　Pediatr Infect Dis J. 39(1) : 85-87, 2020
  8. Benett JC, Suga S, Hayford K, et al.　Changes in Invasive Pneumococcal Disease caused by Streptococcus pneumoniae Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE project.　Microorganisms. 9(4) : 696, 2021
  9. Takeuchi N, Chang B, Ishiwada N, Cho Y, Nishi J, Okada K, Fujieda M, Oda M, Saitoh A, Hosoya M, Ishiguro N, Takahashi K, Ozawa Y, Suga S. Nationwide population-based surveillance of invasive pneumococcal disease in children in Japan (2014–2022): Impact of 13-valent pneumococcal conjugate vaccine and COVID-19 pandemic. Vaccine. 2025 Apr 18; 54: 127138. doi: 10.1016/j.vaccine.2025.127138. Epub ahead of print. PMID: 40252365.
  10. Garcia Quesda M, et al. Serotype distribution of remaining invasive pneumococcal disease after extensive use of ten-valent and 13-valent pneumococcal conjugate vaccine (the PSERENADE project): a global surveillance analysis. Lancet Infect Dis 2025 25(4) : 445-456.
  11. Bennet JC, et al. Global impact of 10- and 13-valent pneumococcal conjugate vaccines on pneumococcal diseases in all ages: The PSERENADE project. Lancet Infect Dis 2025 25(4) : 457-470.
  12. Yang Y, et al. Global impact of 10- and 13-valent pneumococcal conjugate vaccines on pneumococcal meningitis in all ages: The PSERENADE project. J Infect 2025; 90(3) : 106426.
  13. Takeuchi N, Ohkusu M, Kusuya Y, Takahashi H, Yamaguchi M, Omata Y, Nakazawa T, Ishiwada N. Comparative genomic and morphological analyses of capsular and capsular-deficient pneumococcal strains simultaneously isolated from a patient with invasive pneumococcal disease. J Infect Chemother. 2025 Jan; 31(1) : 102486.
  14. Hosoya M, Kume Y, Suyama K, Sato M, Hashimoto K, Go H. Trends in pediatric bacterial meningitis incidence in Fukushima Prefecture, Japan, 1988-2024. Pediatr Int. 2025; 67: e70244. doi: 10.1111/ped.70244.

侵襲性インフルエンザ菌感染症の業績

  1. Ishiwada N, Hishiki H, Nagasawa K, Naito S, Sato Y, Chang B, Sasaki Y, Kimura K, Ohnishi M, Shibayama K. The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines. Vaccine. 32:5425-5431, 2014
  2. Hoshino T, Hachisu Y, Kikuchi T, Tokutake S, Okui H, Kutsuna S, Fukasawa C, Murayama K, Oohara A, Shimizu H, Ito M, Takahashi Y, Ishiwada N. Analysis of Haemophilus influenzae serotype f isolated from three Japanese children with invasive H. influenzae infection. J Med Microbiol. 64: 355-8, 2015
  3. Suga S, Ishiwada N, Sasaki Y, Akeda H, Nishi J, Okada K, Fujieda M, Oda M, Asada K, Nakano T, Saitoh A, Hosoya M, Togashi T, Matsuoka M, Kimura K, Shibayama K. A nationwide population-based surveillance of invasive Haemophilus influenzae diseases in children after the introduction of the Haemophilus influenzae type b vaccine in Japan.　Vaccine. 36:5678-5684, 2018.
  4. Naito S, Takeuchi N, Ohkusu M, Takahashi-Nakaguchi A, Takahashi H, Imuta N, Nishi J, Shibayama K, Matsuoka M, Sasaki Y, Ishiwada N. Clinical and bacteriologic analysis of nontypeable Haemophilus influenzae strains isolated from children with invasive diseases, Japan, 2008-2015. J Clin Microbiol 56. pii: e00141-18, 2018
  5. Hoshino T, Takeuchi N, Ohkusu M, Hachisu Y, Hirose S, Fukasawa C, Kubota T, Ishida M, Watanabe H, Oishi K, Ishiwada N. Identification of Haemophilus influenzae serotype e strains missing the fucK gene in clinical isolates from Japan. J Med Microbiol. 68: 1534-9, 2019

侵襲性B群レンサ球菌感染症の業績

  1. Chang B, Wada A, Hosoya M, Oishi T, Ishiwada N, Oda M, Sato T, Terauchi Y, Okada K, Nishi J, Akeda H, Kamiya H, Ohnishi M, Ihara T, and the Japanese Invasive Disease Study Group. Characteristics of group B Streptococcus isolated from infants with invasive infections: A population-based study in Japan. Jpn J Infect Dis. 67:356-360, 2014
  2. Takeuchi N, Chang B, Takeshita K, Naito S, Takahashi Y, Hishiki H, Ishiwada N. Epidemiology and bacterial characteristics of invasive group B streptococcus disease: a population-based study in Japan in 2010-2020.　Epidemiol Infect. 150: e184, 2022

成人疫学

侵襲性肺炎球菌感染症

  1. Fukusumi M, et al. Invasive pneumococcal disease among adults in Japan, April 2013 to March 2015: Disease characteristics and serotype distribution. BMC Infect Dis 2017 Jan 3; 17(1) : 2.
  2. Shimbashi R, et al. Epidemiological and clinical features of invasive pneumococcal disease caused by serotype 12F in adults, Japan. PLoS One 2019 Feb 21; 14(2) : e0212418.
  3. Shimbashi R, et al. Effectiveness of 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease in adults, Japan 2013-2017. Emerg Infect Dis. 26(19) : 2378-86, 2020.
  4. Chang B, et al. Distribution and variation of serotypes and pneumococcal surface protein A clades of Streptococcus pneumoniae strains isolated from adult patients with invasive pneumococcal disease in Japan. Front Cell Infect Microbiol. 2021, March 19; 11: 617573.
  5. Deloria Knoll M, Global landscape review of serotype-specific invasive pneumococcal disease Surveillance among countries using PCV10/13: The PSERENADE Project. Microorganisms. 9(4) : 742, 2021.
  6. Garcia Quesada M, et al. Serotype distribution of remaining pneumococcal meningitis in the mature PCV10/13 period: Findings from the PSERENADE Project. Microorganisms. 9(4) : 738, 2021
  7. Chang B, et al. Pneumococcal Meningitis in Adults in 2014-2018 after Introduction of Pediatric 13-valent Pneumococcal Conjugate Vaccine in Japan. Sci Rep 2022 Feb 23; 12(1) : 3066.
  8. Tamura K, et al. Dynamic changes in clinicalcharacteristics and serotype distribution of invasive pneumococcaldisease among adults in Japan after introduction of the pediatric 13-valent pneumococcal conjugate vaccine in 2013-2019． Vaccine 40: 3338-44, 2022 doi: 10.1016/j.vaccine.2022.04.062.
  9. Chang B, et al. Invasive Streptococcus oralis expressing serotype 3 pneumococcal capsule, Japan. Emerg Infect Dis　28（8）：1720-22, 2022　
  10. Tamura K, et al. Unveiling the role of preceding seasonal influenza in the development of bacteremic pneumococcal pneumonia in older adults before the COVID-19 pandemic in Japan. 2024 Int J Infect Dis 143: 107024. 
  11. Garcia Quesda M, et al. Serotype distribution of remaining invasive pneumococcal disease after extensive use of ten-valent and 13-valent pneumococcal conjugate vaccine (the PSERENADE project) : a global surveillance analysis. Lancet Infect Dis 2025 25(4) : 445-456.
  12. Bennet JC, et al. Global impact of 10- and 13-valent pneumococcal conjugate vaccines on pneumococcal diseases in all ages: The PSERENADE project. Lancet Infect Dis 2025 25(4) : 457-470. 
  13. Yang Y, et al. Global impact of 10- and 13-valent pneumococcal conjugate vaccines on pneumococcal meningitis in all ages: The PSERENADE project. J Infect 2025; 90(3) : 106426.
  14. Kawamura M, et al. A Case of Infectious Endocarditis and Vertebral Discitis Caused by Streptococcus pneumoniae Serotype 23A. J Infect Chemother 2025, 31: 102749.
  15. Ishii S, et al. Skull base osteomyelitis caused by serotype 3 Streptococcus pneumoniae in a healthy 1-year-old girl. Pediatr Int 2025, 67: e70259. 
  16. Akazawa H, et al. Hospital-acquired pneumonia caused by multidrug-resistant Streptococcus pneumoniae serotype 15A. Infection 2025. Online ahead of print.
  17. Shimbashi R, et al. A pluralistic approach to interpreting surveillance data: The likely decline in the occurrence of invasive pneumococcal disease in Japan during the COVID-19 pandemic. Ann Epidemiol 2025 108: 63-70.

侵襲性インフルエンザ菌、侵襲性髄膜炎菌球菌感染症、劇症型溶血性レンサ球菌感染症

  1. Hachisu Y, et al. Invasive Haemophilus influenzae Disease among Adults in Japan during 2014–2018. Infection 51(2) : 355-64, 2023.
  2. Kobayashi M, et al. Epidemiology of invasive meningococcal disease, Japan, 2013 to 2023. Euro Surveill 2024 Nov 14; 29(46) : 2400136.
  3. Tsuchihashi Y, et al. Comparative analysis of streptococcal toxic shock syndrome caused by three β-hemolytic streptococcal species in Japan．Int J Infect Dis 2025 Sep; 158 : 107962.